Diet and Nutrition – Vitamins B6

Vitamin B6 occurs in three forms–pyridoxine, pyridoxamine, and pyridoxal. B6 is absorbed in the large intestine. The muscle stores more or less 75 80 % of the vitamin although the live stores about 5 10 %.

B6 is necessary for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde class works as a Schiff base to react with the amino groups of amino acids. It basically acts to shuttle nitrogen between compounds.

Functions- The 3 forms of B6 can all be converted to the coenzyme PLP which helps in transamination and protein metabolism. PLP is important for glycogen degradation; it also helps with the formation of the neurotransmitter, serotonin, the nonprotein part of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolic rate of tryptophan to niacin.

General Reactions:

· Transaminations These responses are required to recycle as well as reuse nitrogen in the entire body. They’re the initial phase in amino acid catabolism and also the very last phase in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate

· Serine/ Threonine Deamination (Dehydratases) This reaction provides the production of the a-keto acids of serine as well as threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+

· Decarboxylation These reactions typically appear on the neuroactive amines of GABA., histamine, tyramine, and seratonin They also are critical in porphyrin synthesis, intermediates inside the synthesis of sphingomyelin, lecithin and taurine, as well as for the breakdown and desulfuration of cysteine.

· Glycogen Phosphorylase 50 % of all B6 in the body is likely to glycogen phosphorylase though the value is unknown. meal prep is vital for recycling of folate and is as follows:

Serine glycine + 5,10-methylene-THF

Deficiency Deficiencies of vitamin B6 are fairly uncommon. People with a diet deficient in vitamin B6 will 1st show signs of weakness, irritability, insomnia, nervousness, and hydrated skin lesions. Much more advanced symptoms consist of growth failure, impaired motor function, hypochromic microcytic anemia, sleek tongue, and convulsions.

The impaired motor function as well as other psychological issues could be attributed to a decrease in amino acid-based neurotransmitters (serotonin, GABA, tyramine, epinephrine). You see a growth in urea excretion due to a decrease synthesis of nonessential amino acids. The nitrogen from these amino acids is not reused by transamination and instead is excreted and lost. You see a rise in urinary excretion particularly inside the following amino acids: metabolites of glycine, methionine, and tryptophan. The hypochromic microcytic anemia is mainly because that there’s a lowered synthesis of the B6 dependent porphyrin ring of hemoglobin.

Those who are at most risk are the older folk with inadequate vitamin intake, hemodialysis patients, alcoholics, and those who are on drug therapy. General, individuals with an impressive metabolic stress.

Sources Foods richest in vitamin B6 include:

o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin and chicken) o fish (salmon and shellfish) o bananas and apples o broccoli and spinach

Therapeutics Vitamin B6 could provide therapeutic advantages for the next syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic problems, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (pms) and Immune function. Moreover, vitamin B6 may well help to reduce homocysteine levels and thus the chance of getting cardiovascular disease.

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